Centre for Advanced Neurological Research

Dr Lekha Pandit is the Principal Investigator of this center , located at KS Hegde Medical Academy. Its strength and uniqueness comes from the fact that it is a clinician driven research center which focuses on translational research in autoimmune central nervous system disorders. Its broad goals are to utilize clinical longitudinal data derived from its large patient registry to ask basic research questions that have translational potential through identification of biomarkers, immunological targets that facilitate management algorithms and the development of cost effective bioassays. These include a number of autoimmune disorders with special emphasis on multiple sclerosis (MS), Neuromyelitis optica spectrum disorders(NMOSD) and a variety of atypical non MS demyelinating diseases.

Dr Lekha Pandit

Professor of Neurology & Director

Dr Lekha Pandit

DesignationProfessor of Neurology & Director
Email panditmng@gmail.com
Contact No.08242204471 ext
Joining date 2000-06-16

My academic interests are focused on central nervous system demyelinating disorders and in particular Multiple sclerosis (MS) and neuromyelitis optica spectrum disorders (NMOSD). Since 2007 I have established a registry for demyelinating CNS disorders at my university, in the south west part of India at Mangalore. This registry has patients from around 300 sq. kilometer radius and beyond and is one of the few dedicated to the study and care of patients suffering from demyelinating central nervous system disorders in India. In the past decade we have studied the clinical and demographic features of these disorders, conducted longitudinal follow up studies and published the first population based prevalence study in our country. Simultaneously we have, based on our experiences, established cost effective treatment algorithms for management of patients in resource poor settings which has now become standard of care in our part of the world. I have additionally special interest in the characterization of optic neuritis, particularly in detection of clinically silent disease using optical coherence tomography and specialized electro retinography . Alongside clinical work, I have researched and published my work on the genetic susceptibility for MS and NMOSD in south Indian population. Our studies support the notion that ethnicity may not be a significant contributing factor that influences genetic susceptibility for these diseases. My lab is currently funded for developing novel diagnostic biomarkers and animal models for studying NMOSD. My responsibilities have additionally included teaching of medical undergraduates, post graduates in Internal medicine ,Psychiatry and Pediatrics and providing guidance for PhD students in my lab.

Educational Qualifications

MD, DM (Neurology), PhD

Past Experience

June 1982-May1985	:	Completed postgraduate training in Internal Medicine during which period taught Clinical Medicine to undergraduates.
January 1986-December 1988	:	Completed Post-Doctoral Fellowship (DM) in Neurology during which period actively participated in teaching undergraduates, postgraduates in Medicine, Psychiatry and Paediatrics.
April 1990-January 1995	:	Worked as Assistant Professor in Neurology. During this period has organized and actively participated in teaching undergraduate and post-graduates in Medicine, Paediatrics and Psychiatry. Actively involved in the training programme for DM post-graduates and was in charge of organizing and implementing the teaching programs. Also conducted bedside teaching, delivered lectures and moderated seminars, journal clubs and other academic activities. Responsibilities included the task of setting entrance examination question papers for selection of DM postgraduates.
January 1995 -1998	:	Working as Associate Professor in Neurology,Kasturba Medical College, Manipal and Mangalore, India. Was responsible for setting up the neurology intensive care unit at University Medical centre( the superspeciality hospital of Kasturba Medical College, Mangalore). In addition to routine academic work, was also a guide for MD Medicine postgraduates.
June 2000 â€“December 2015	:	Working as Professor of Medicine (Neurology), involved in teaching final year medical undergraduates and post graduates in Medicine, Pediatrics & Psychiatry.
April 2007- Present	:	Director, Center for Advanced neurological research. This center which was set up with modest philanthropic donations in 2007, is the first and only clinician driven basic science center at Nitte (Deemed to be University). It grew in stature from a modest PCR laboratory to a research facility with capability for real time PCR work, cell culture and bioassay and Flowcytometry. It is a recognized center for the awarding of PhD in Biosciences.
January 2016 onwards	:	Professor and Head, Department of Neurology, KS Hegde Medical Academy, Nitte (Deemed to be University).
August 2018 - January 2019	:	Visiting Professor, Department of Neurology, Harvard medical School (Brigham and Women's Hospital)
February 2019 onward	:	Professor of Neurology & Director of Center for Advanced Neurological Research

Research Training and Experience

Research Fellowship in the United Kingdom- (1995-1997). Worked as Research Fellow in Clinical Neurology (Demyelinating disorders) at Royal Victoria Infirmary, Newcastle and Research Associate at the University of Newcastle, United Kingdom. Worked on the following projects (see publications)
1. Evaluation of the effect of I.V. Methyl prednisolone on the Cytokine Profile (tumour necrosis factor – alpha) and soluble adhesion molecules (VCAM I and ICAM I) in Multiple Sclerosis.
2. Assessment of disability in Multiple sclerosis-a clinical and radiological study.
3. Research associate and local (Newcastle) treating physician for the following trials
Research Associate –Department of Molecular and Fisheries Microbiology, College of Fisheries, University of Agricultural Sciences, Mangalore, Karnataka. (2000- 2003). Worked on the following projects (See publications)
1. Evaluation of the use of universal primers – (16s rRNA) in the diagnosis of Culture negative meningitis.
2. Use of seminested PCR strategy in the diagnosis of culture negative meningitis
3. Diagnostic utility of Methylation PCR in the evaluation of fragile X Mental retardation.
4. Molecular diagnosis of Campylobacter jejuni infection in Guillain Barre Syndrome.
Research training in Multiple sclerosis Genetics – University of Cambridge (December 2009-2010 April). Worked as the Jaquelline Du Pre awardee of 2009-2010 in The Department of Neurology, Addenbrookes Hospital, Cambridge, UK.

Areas of Interest

Autoimmune central nervous system disorders

Achievements

Visiting Professor, Department of Neurology, Harvard medical School (Brigham and Women's Hospital) - August 2018- January 2019.
Fulbright-Nehru Scholar (Academic & Professional Excellence)-2018.
Nominated as member/ Chairperson of the Institutional ethics committee of Sree Chitra Tirunal Institute for Medical Sciences & Technology - 2017- 2018.
Nominated Member, Central Organizing Committee of Pan Asian committee for treatment and research in Multiple sclerosis ( PACTRIMS) - 2015 - present
Nominated member of International Medical Consortium- Guthy Jackson Neuromyelitis optica (NMO) foundation, USA-2013- present
Member of the advisory group, World atlas of Multiple sclerosis, 2nd edition, Multiple Sclerosis International federation (MSIF) - 2012 -2013.
National Convenor, Indian Academy of Neurology- subsection on Autoimmune CNS disorders - 2013- 2017.
India representative at Multiple sclerosis International federation (MSIF) -2009-2011.
India representative at Asia Pacific Expert committee on Multiple sclerosis (APEC) - 2011-2013
Best researcher and Investigator award for work on "Genetic susceptibility for Multiple sclerosis in Indian population" by Pan Asian Committee for treatment and Research in Multiple sclerosis [PACTRIMS] -2010.
Jaquelline du Pre Grant from Multiple sclerosis International federation, United Kingdom - 2010-2011.
Rhodes Scholar Mridula Shastri memorial fellowship -1995.

Departmental Responsibilities

Undergraduate and post graduate teaching and guideship for PhD students

Professional Memberships

List of Membership in Academic Bodies

Permanent member, Neurological Society of India
Permanent member, Indian Academy of Neurology
Life Member, Multiple Sclerosis society of India
Member, National Medical Panel for Multiple sclerosis
Member, International medical and scientific board of Multiple sclerosis International federation (MSIF)
Life member, Indian Society of Human Genetics

List of Professional reviews

Multiple Sclerosis and related disorders
Multiple sclerosis Journal
Multiple Sclerosis Clinical Experimental &Translational
Journal of Neurological sciences.
BMC Neurology
Journal of Neurology, Neurosurgery, Psychiatry
Frontiers Neurology

List of National reviews

Neurology India
Annals of academy of Neurology

Subjects Handled

Neurology

Conferences/CME/Workshops

Task Force meeting on "National Multiple Sclerosis and Allied Demyelinating Disorders Registry and Research Network of India". Pandit L - Running a registry and optimising data collection at National institute of medical statistics, ICMR, New Delhi. 23.10.2019
Pandit L - Treatment challenges in MOG-IgG disease, in the plenary session of the first congress of Sri Lanka committee for Treatment and Research in Multiple sclerosis and related disorders, at Colombo on 5th October, 2019.
Pandit L -Gut Microbiome in Autoimmune CNS disorders among Indian population - at the Annual conference of the Indian Academy of Neurology, at Hyderabad, India on 4th October, 2019.
Pandit L presented a poster at the 35th congress of the European Committee for Treatment and Research in Multiple Sclerosis (ECTRIMS) and the 24th Annual conference of Rehabilitation in MS (RIMS), titled " Lachnoclostridium species are elevated in Aquaporin-4 IgG+ Neuromyelitis Optica Spectrum Disorders in India and exhibit sequence similarity with AQP4" (11-13 September 2019 Stockholm, Sweden) .
Pandit L was invited as the Multiple Sclerosis expert from Asia Pacific region for the meeting of the International Working Group on Access to treatment (IWGA) for Multiple Sclerosis (11-12th July 2019, London)
Pandit L was an invited principal speaker and chairperson for Neuro Immunology session at 1st East Zone Neuro PDT CME 2019 (May 2019, Kolkata).
Pandit L. Demyelinating CNS Disorders in women with emphasis on MS and NMO. Invited speaker at Women In Neurology- New & Emerging Research Symposium (March 2018, Udaipur).
Pandit L was invited to attend and present in the Guthy -Jackson Charitable foundation 's Annual NMO Roundtable Conference March 2018
Pandit L. Autoimmune Encephalitis. Invited speaker at the 10th Congress of the Pan-Asian Committee for Treatment and Research in Multiple Sclerosis (PACTRIMS) in November 2017 at Ho Chi Minh City, Vietnam.
Pandit L was invited to attend and present in the Guthy -Jackson Charitable foundation 's Annual NMO Roundtable Conference 2017 from, March 12th to14th 2017
Pandit L. Differentiating Multiple Sclerosis from NMOSD in the clinic. Invited speaker at IANCON, Kolkata November 2016
Pandit L. Characterization of seronegative neuromyelitis optica in 2016. Paper presented at ECTRIMS, United Kingdom September 2016,
Pandit L. Different approaches in diverse clinical settings in Multiple sclerosis management - 'Ideal' vs practical realities of 'Real world'. Talk delivered at MS Expert meeting (Biogen), Athens, Greece, May 2016.
Pandit L was invited to attend the Guthy -Jackson Charitable foundation 's Annual NMO Roundtable Conference 2016 from February29-March 1,2016
Pandit L. Demyelinating disorders in India- an over view- Invited lecture at national meeting of Association of Physicians of India (APICON), Hyderabad, January 2016.
Pandit L. Role of Biomarkers in the diagnosis and management of optic neuritis. Invited speaker at Synapse 2016,Shankar Nethralaya, Chennai , January2016.
Pandit L, Sato D, Mustafa S et al. Characterization Of Anti MOG and Anti AQP4 Antibody Associated NMOSD in South India. Paper presented at PACTRIMS, Seoul, Korea, November 2015.
Pandit L. Management of Multiple Sclerosis and Neuromyelitis Optica Spectrum Disorders in Resource Poor Settings. Invited speaker at PACTRIMS, Seoul, Korea, November 2015.
Pandit L, Mustafa S, Malli C et al. Anti MOG antibody associated disease is distinct from Anti AQP4-IgG associated Neuromyelitis Optica Spectrum disorders . Paper presented at IANCON 2015,Agra.
Pandit L. Gene environmental interactions in Neuromyelitis optica. Invited speaker at the plenary session of Guthy Jackson Foundation International symposium, Los Angeles, USA, March 2015
Pandit L Challenges in the diagnosis and management of neuromyelitis optica spectrum disorders. Invited speaker at Karnataka association of neurology annual meeting, February 2015, Mangalore.
Pandit L , Malli C, D'Cunha A et al .HLA class II alleles and environmental associations with neuromyelitis optica in Indian population.ECTRIMS 2014 in Boston, Massachusetts, USA.
"Pandit L: Invited speaker at panel discussion on treatment choices for Multiple Sclerosis in India. Annual conference of Indian Academy of Neurology, Chandigarh, November 2014.
Pandit L. Delivered keynote address on "The end points in MS disease evaluation: Clinical disability vs. relapse rate vs. Imaging" at NEUCON-Controversies in Neurology, Hyderabad 2014.
Pandit L. Multiple sclerosis therapeutics- Invited speaker at Dr Balaparameshwara symposium on therapeutic advances in Neuroimmunology, at Andrapradesh Neurological Society Conference, Tirupathi, June, 2014.
Pandit L, Malli C, D'Cunha A et al. Selective association of HLA -DRB1 alleles with Multiple Sclerosis susceptibility in Indian population. Paper presented at ECTRIMS, Copenhagen (October 2013).
Pandit L. Genetics of multiple sclerosis in Indians. Invited speaker at the plenary session of PACTRIMS, Kyoto, Japan (November 2013).
Pandit L. Neuromyelitis spectrum disorders in India. Invited speaker at the roundtable conference of the Guthy Jackson foundation, Los Angeles, California, USA (November 2013).
Pandit L. Neuromyelitis spectrum disorders. Invited speaker at Tropicon 2013, Tropical neurology Subsection of Indian Academy of Neurology, Guwahati, Assam (February 2013).
Pandit L. Treatment options In Multiple Sclerosis. Invited speaker at the Continuing medical association program, Annual meeting of Neurological society of India, New Delhi(December 2012)
Pandit L, Malli C, Shetty R et al. Environmental factors associated with Multiple Sclerosis. Invited talk at annual meeting of association of Sri Lankan neurologist, Colombo, SriLanka (November 2012).
Thompson AJ, Browne P, Taylor B, Battaglia M, Pandit L, Tremlett H, Uitdehaag B, Holloway E. MSIF Atlas of MS Database update: Multiple sclerosis resources in the world 2013. Paper presented at ECTRIMS, Lyon, France (October 2012).
Pandit L, Kundapur R. Mangalore model of epidemiological survey-a method for establishing minimal prevalence for demyelinating disorders in resource poor countries. Paper presented at PACTRIMS2012, Beijing, China (September 2012).
Pandit L, Shetty R, Singhal B et al. Environ mental factors associated with Multiple scleropsis in India. Are they different from the west?Paper presented at annual conference of Indian Academy of Neurology (September 2012, Ahmadebad).
Pandit L. Treatment practices for Multiple sclerosis in India. Invited speaker at Asia pacific expert committee (APEC) meeting, Hongkong, July 2012.
Pandit L. Differential diagnosis of white matter diseases. Invited lecture, Kannur Neuro Club, April2012, Kerala.
Pandit L, Singhal B, Shetty R et al. Epstein -Barr serology in central nervous system demyelinating disorders from a south Indian disease registry. Poster presented at ECTRIMS (Sept 2011).
Pandit L. Genetics of Multiple sclerosis in India. Invited presentation at the plenary session of PACTRIMS 2011 (Singapore, June 2011) 3
Pandit L. Oral medications for Multiple sclerosis. Invited speaker at the national meeting on controversies in neurology Neucon2011 (Mumbai, June 2011)
Pandit L. Insights into MS in India. Invited speaker at the annual meeting of Kerala Association of neurologists (May2011, Wyanad, Kerala).
Pandit L, Ban M, Stephen Sawcer et al. Genetic risk factors for Multiple Sclerosis in Indians-Do they differ from western population? PACTRIMS, 2010.

Conference/Journal publications

Pandit L, Cox L, Malli C, D'Cunha A, Rooney T, Chitnis T et al. C.bolteae is elevated in NMOSD in India and shares sequence similarity with AQP4. Neurol Neuroimmunol Neuroinflamm 2020 (In print).
Pandit L, Malli C, D'Cunha A, Sudhir A. Role of Viral Infections in Multiple Sclerosis pathogenesis among Indian Population. Neurol India2020 (In print).
D'Cunha A, Pandit L, Malli C, Sudhir A. Evaluating the role of HLA DRB1 alleles and oligoclonal bands in influencing clinical course of Multiple Sclerosis- A study from the Mangalore demyelinating disease registry . Ann Indian Acad Neurol 2020(In print).
Whittam D H, Karthikeayan V, Gibbons E, Kneen R, Chandratre S, Ciccarelli O, Hacohen Y, Pandit L et al. Treatment of MOG antibody associated disorders: results of an international survey. J neurol2020; doi: 10.1007/s00415-020-10026-y.
Tenembaum S, Yeh EA and the Guthy-Jackson Foundation International Clinical Consortium (GJCF-ICC). Pediatric NMOSD: A Review and Position Statement on Approach to Work-Up and Diagnosis. Front. Pediatr 2020; 8: https://doi.org/10.3389/fped.2020.00339.
Hor J Y, Asgari N, Nakashima I, Broadley S A, Leite M I, Kissani N, Jacob A, Marignier R, Weinshenker B G, Paul F, Pittock S J, Palace J, Wingerchuk DM, Behne JM, Yeaman M R and Fujihara K on behalf of the Guthy-Jackson Charitable Foundation International Clinical Consortium for NMOSD. Epidemiology of Neuromyelitis Optica Spectrum Disorder and Its Prevalence and Incidence Worldwide. Front. Neurol 2020: https://doi.org/10.3389/fneur.2020.00501
Whittam D H, Cobo-Calvo A, Lopez-Chiriboga A S, Pardo S, Gornall M, Cicconi S, Brandt , Berek K, Berger T, Jelcic I, Gombolay G, Pandit L et al. Treatment of MOG-IgG-associated disorder with rituximab: an international study of 121 patients. Mult Scler Relat Disord 2020: DOI: 10.1016/j.msard.2020.102251
Bhatia R, Padma Srivastava M V, Khurana D, Pandit L, Mathew T, Gupta S, Netravathi M, Nair SS, Singh G ,Singhal BS. Consensus Statement on Immune Modulation in Multiple Sclerosis and Related Disorders during the COVID‑19 Pandemic: Expert Group on Behalf of the Indian Academy of Neurology. Ann Ind Acad Neurol 2020;23:5-14
Cook L J, Rose J W, Alvey J S, Jolle A M, Kuhn R, Yeaman M R on behalf of The Guthy-Jackson Charitable Foundation International Clinical Consortium (GJCF-ICC).Collaborative International Research in Clinical and Longitudinal Experience Study in NMOSD.Neurol Neuroimmunol Neuroinflamm 2019;6 (5): e583.
Pandit L. No evidence of disease activity (NEDA) in multiple sclerosis - Shifting the goal posts .Ann Ind Acad Neurol 2019; 22: 261-263.
Pandit L, Mustafa S, Nakashima I et al. MOG-IgG-associated disease has a stereotypical clinical course, asymptomatic visual impairment and good treatment response Mult Scler J Exp Transl Clin. 2018;4(3) : 1-9.
Pandit L, Mustafa S, Uppoor R et al. Reversible paraspinal muscle hyperintensity in anti-mog antibody-associated transverse myelitis. Neurol Neuroimmunol Neuroinflamm 2018; 5:e412.
Pandit L, Nakashima I, Mustafa S et al. Anti Myelin Oligodendrocyte Glycoprotein associated Immunoglobulin G (AntiMOG‑IgG)‑associated Neuromyelitis Optica Spectrum Disorder with Persistent Disease Activity and Residual Cognitive Impairment. Ann Ind Acad Neurol 2017; 20:411-3.
Pandit L, Mustafa S. Spontaneous remission lasting more than a decade in untreated aqp4antibody-positive NMOSD. Neurol Neuroimmunol Neuroinflamm 2017;4:e351.
D'Cunha A, Pandit L, Malli C. Genetic variations in the Dravidian population of South West coast of India: Implications in designing case-control studies. Indian J Med Res 2017;145: 753-757
Steinman L, Bar-Or A, Behne JM, et al. Restoring immune tolerance in neuromyelitis optica: Part I. Neurol Neuroimmunol Neuroinflamm. 2016;3(5):e276.
Bar-Or A, Steinman L, Behne JM, et al. Restoring immune tolerance in neuromyelitis optica: Part II. Neurol Neuroimmunol Neuroinflamm. 2016;3(5):e277
Pandit L, Sato D, Mustafa S et al. Serological markers associated with NMO spectrum disorders in south India .Ann Indian Acad Neurol 2016;19:505‑509
D'Cunha A, Pandit L, Malli C. CD6 gene polymorphism rs17824933 is associated with multiple sclerosis in Indian population. Ann Ind Acad Neurol 2016;19:491‑494
Pandit L, Sato D, Mustafa S et al. Relapsing optic neuritis and isolated transverse myelitis are the predominant clinical phenotypes for patients with antibodies to myelin oligodendrocyte glycoprotein in India. Mult Scler J Exp Trans Clinic 2016; 2:1-5.
Pandit L, Maria B, Beecham AH et al. European multiple sclerosis risk variants in the south Asian population. Mult Scler 2016; 22(12):1536-1540.
Pandit L, Malli C, Singhal B et al. HLA association in South Asian Multiple Sclerosis. Mult Scler 2016;22(1):19-24
Juryńczyk M, Weinshenker B, Pandit L et al. Status of diagnostic approaches to AQP4-IgG seronegative NMO and NMO/MS overlap syndromes. J Neurol. 2016; 263(1):140-9.
Pandit L. Neuromyelitis optica spectrum disorders-an update. Ann Ind Acad Neurol 2015; 18:S11:15.
Weinshenker BG, Barron G, Behne JM, Guthy-Jackson Charitable Foundation International Clinical Consortium. Challenges and opportunities in designing clinical trials for neuromyelitis optica. Neurology2015 28;84(17):1805-15
Melamed E, Levy M, Pandit L et al. Update on Biomarkers in Neuromyelitis Optica. Neurol Neuroinflam 2015 23; 2(4):e134.
Kim HJ, Paul F, Lana-Peixoto MA, Guthy-Jackson Charitable Foundation NMO International Clinical Consortium & Biorepository. MRI characteristics of neuromyelitis optica spectrum disorder: an international update. Neurology 2015 Mar 17; 84(11):1165-73.
Kremer S, Renard F, Achard S , Guthy-Jackson Charitable Foundation NMO International Clinical Consortium. Use of advanced MRI techniques in Neuromyelitis optica spectrum disorders. JAMA Neurol. 2015;72(7):815-822.
Pandit L, Malli C, D'Cunha A et al. HLA association in Neuromyelitis Optica in Indian population . Mult Scler 2015; 21(9):1217-8.
Bennett JL, Seze J de, Peixoto ML, Guthy-Jackson Charitable Foundation NMO International Clinical Consortium & Biorepository et al.Neuromyelitis optica and multiple sclerosis: Seeing differences through optical coherence tomography. Mult Scler 2015;21(6):678-88.
Malli C, Pandit L, D'Cunha A et al. Environmental factors related to Multiple sclerosis in Indian population. 2015 PLoS ONE 10(4): e0124064.
Pandit L, Asgari N, Apiwattanakul M et al. Demographic and Clinical features of Neuromyelitis optica- A review. Mult scler 2015; 21(7):845-53.
Pandit L, Mustafa S. Mycophenolate in the treatment of Multiple Sclerosis- A preliminary report. Neurol India 2014; 62: 646- 648.
Mustafa S, Pandit L. Approach to diagnosis and management of optic neuropathy. Neurol India 2014; 62: 599- 605.
Pandit L, Kundapur R. Prevalence and patterns of demyelinating central nervous system disorders in urban Mangalore, South India in India. Mult Scler 2014; 20:1651-3.
Pandit L,Mustafa S. Optimizing the management of Neuromyelitis Optica and Spectrum disorders in resource poor settings: Experience from the Mangalore demyelinating disease registry. Ann Ind Academy Neurol.2013; 16: 572- 576.
Pandit L, Ramagopalan SV, Malli C, D'Cunha A, Kunder R, Shetty R, Association of vitamin D and multiple sclerosis in India. Mult Scler 2013; 19:1592- 1596.
Pandit L, Malli C, D'Cunha A et al. Association of Epstein-Barr virus infection with multiple sclerosis in India. J Neurol Sci 2013;325: 86-89.
Pandit L, Shetty R, Misri Z et al. Optic neuritis: Experiences from a south Indian demyelinating disease registry. Neurol India 2012; 60: 470-475
Pandit L. Insights into the changing perspectives of multiple sclerosis in India. Autoimmune diseases.2011, Doi:10.4061/2011/937586.
Pandit L, Murthy JMK. Treatment of Multiple Sclerosis. Ann Ind Acad Neurol. 2011;14: 65-69.
Pandit L, Ban M, Sawcer N et al. Evaluation of the established non-MHC Multiple Sclerosis loci in an Indian Population. Mult Scler 2011; 17:139-143.
Pandit L, Ban M, Sawcer N et al. Genetic risk factors for multiple sclerosis in Indians: Do they differ from western populations? Mult Scler 2010; 16: S1268- S1273
Pandit L, Shetty R, Mustafa S et al. Optic spinal MS in India is distinct from NMO - Clinical and HLA class 11 association studies. Mult Scler 2010; 16: S263-S280.
Pandit L, Shetty R, Bhat IG et al. Seronegative neuromyelitis spectrum disorders in India. Mult Scler 2009; 5: S15-S269.
Pandit L. Mitoxantrone in MS-Invited commentary. Neurol India 2009; 57:424-425.
Pandit L. Transverse myelitis spectrum disorders. Neurol India 2009; 57:126-132.
Pandit L.. Differential diagnosis of white matter diseases in the tropics. Ann Indian Acad Neurol 2009;12:12-21.
Pandit L. Neuromyelitis optica antibody (NMO-IgG) status in Indian patients with multiple sclerosis and allied demyelinating disorders. Neurol Asia 2008; 13 : 175- 178.
Pandit L NMO-IgG in Indian patients with Multiple sclerosis & allied idiopathic inflammatory demyelinating disorders of the central nervous system. Mult Scler 2009; 15:131-136.
Pandit L, Shetty R, Bhat IG et al .Anti - Aquaporin 4 antibody seropositivity in Multiple Sclerosis and allied demyelinating disorders in Indian patients. Ann Ind Acad Neurol 2008; 11(S2)138-139.
Pandit L Multiple sclerosis and allied demyelinating disorders in India. Advances in clinical neurosciences and rehabilitation (ACNR) 2008; 8:30-31.
Pandit L, Shetty R, Bhat IG et al. Spectrum of Multiple Sclerosis and related demyelinating disorders in India in the background of revised diagnostic criteria Ann Ind Acad Neurol 2007;10: (S2) 44-45.
Pandit L, Pai M, Shankar SK et al. Multifocal tumour like presentation of white matter- a case report. Neurol India. 1998; 46 : S96
Pandit L, Beveridge C, Coulthard C et al. Predictors of disability in Multiple sclerosis. Neurol India.1998; 46: S67- 68.
Pandit L, Dickenson A, Bates D. Cytokine and Adhesion molecule profile in Multiple Sclerosis patients following Intravenous High dose Methyl Prednisolone. Neurol India. 1997; 45:S66-67.
Pandit L, Coulthard C, Bates D. Clinical and Radiological correlation of disability in Multiple Sclerosis. J Neurol Neurosurg Psychiatry1997; 63:262- 272.
Pandit L, Rao SN. Multiphasic Disseminated Encephalomyelitis. Neurology India 1998; 46:74-75.
Pandit L, Rao S N. Recurrent Myelitis. Journal of Neurology Neurosurgery and Psychiatry 1996; 60: 336-338.
Pandit L, Subramania R, Rao S N. Multiple Sclerosis in Costal Karnataka. Neurol India 1993;41: 143-146.

Chapters in Books:

Pandit L. Demyelinating disorders of the CNS. In: Kamath S (ed). API textbook of Medicine.11th ed. CBS publishers; 2019; 2047-2053
Pandit L. Neuromyelitis Optica Spectrum Disorders. In: IAN Textbook of Neurology: Jaypee Brothers; 2018; 454-462
Pandit L. Demyelinating disorders in India-An update In: Wander GS (ed) Medicine Update Mumbai: Jaypee Brothers; 2016; 1111-1116
Singhal BS, Pandit L. Multiple sclerosis in the tropics. In: Chopra & Sawhney (eds). Neurology in the tropics.11nd ed. Elsevier Asia.2015:753-763.
Pandit L, Jacob A. Neuromyelitis and spectrum disorders. In: Chopra & Sawhney (eds). Neurology in the tropics.11nd ed. Elsevier Asia ,2015;764-774
Pandit L, Mustafa S. Optic neuropathy in the India; a brief overview. In: Singh G, Das SK (eds) Reviews in Neurology, New Delhi: Elsevier India; 2014: 24-28.
Pandit L. Multiple sclerosis: Treatment options. In: Singh VP, Nair MD (eds). Progress in Clin Neuroscience, Vol. 27. New Delhi: Byword Books; 2013: 62-70.
Pandit L. Immunology & Immunogenetics of Multiple sclerosis. In: Taly AB,Singh,G.(eds) Reviews in Neurology . CME program of Indian Academy of Neurology; 2009
Agrawal A, Dhaval P, Pandit L. Stroke in Pregnancy in Candolotti JT and Burnside JE ( eds).women and stroke research, Nova Publishers,2008
Agrawal A, Dhaval P, Pandit L. Tumor and stroke in Candolotti JT and Burnside JE ( eds).women and stroke research, Nova Publishers,2008
Agrawal A, Dhaval P, Pandit L. Cerebral venous thrombosis in Candolotti JT and Burnside JE ( eds).women and stroke research, Nova Publishers,2008.
Agrawal A, Dhaval P, Pandit L. Stroke in developing countries, in Candolotti JT and Burnside JE ( eds).women and stroke research, Nova Publishers,2008
Pandit L. Impact of Molecular Genetics on the diagnosis and management of neurological disorders. In: Radhakrishnan K (ed) Reviews in Indian Neurology 2005, Indian Academy of Neurology CME Publication; 2005: 33-46,
Pandit L. Demyelinating disorders of the Central Nervous System with relevance to India. In: Radhakrishnan K (ed) Reviews in Indian Neurology 2004, Indian Academy of Neurology CME Publication;2004: 65-79.
Pandit L. The role of PCR in the diagnosis of CNS infections: a developing country perspective. In: Radhakrishnan K (ed) Reviews in Indian Neurology 2003, Indian Academy of Neurology CME Publication;2003: 50-71
Pandit L. Immunogenetics in Neurological disorders -An overview. Progress in Clinical Neurosciences 1995; 10: 63-81.

Other publications:

Pandit L. Coexistence of autoimmune diseases and autoantibodies in patients with myasthenia gravis. Neurol India 2016;64:7
Raghotham A, Pandit L. Large unruptured proximal (A1) anterior cerebral artery aneurysm with aplasia of the contralateral A1.Neurol India 2014; 62:80- 82.
Pandit L, Chickabasaviah Y, Ragotham A et al. Neoplastic Parkinsonism- An illustrative case report . Ann Ind Acad Neurol 2013; 16:441- 443.
Pandit L, Yasha M, Anandan N et al. Lymphomatosis cerebri -a rare cause of leucoencephalopathy . J Neurol Sci 2010: 293:122-124.
Pandit L, Narayanappa G, Bhat IG et al. Autosomal recessive tubular aggregate myopathy in an Indian family. Eur J Paed Neurol. 2009; 13:373-375
Pandit L, Agrawal A, Mudgal S et al. Tuberculous spinal meningitis - a treatable cause of myeloradiculopathy. Infect Dis Clin Pract.2009; 17:281-282.
Agrawal A, Joharapurkar SR, Pandit L et al. Infect Disease Clin Pract.2008; 16: 345-348.
Agrawal A, Jake T, Pandit L et al. Management of subdural hematoma. Infect Disease Clin Pract.2007; 15:149-153
Agrawal A, Pandit L, Bhandary S et al: Diagnostic and therapeutic aspects.. Singapore Med J 2007; 48: e181-185.
Agrawal A, Shetty MS, Pandit L et al. Post-traumatic syringomyelia. Ind J Orthop 2007;41:398-400
Pandit L, Gayathri N, Shetty L et al. Adult onset Leigh syndrome - a case report. Ann Indian Acad Neurol 2007;10:55-57.
Agrawal A, Pandit L, NayakV, et al. Pre-Chiasmatic nerve injury following frontal contusion. Eur J Gen Med 2007;4:45-47.
Agrawal A, Timothy J, Pandit L et al. Neurogenic pulmonary odema. Eur J Gen Med. 2007;4 :25-32
Pandit L, Agarwal A. Neuromuscular dysfunction in critical illness. Clinical Neurol Neurosurgery. 2006; 108: 621-627.
Pandit L, Agrawal A. Cryptococcal meningitis in a non HIV patient. Eur J Gen Med 2006;3:80-82
Agrawal A, Pandit L. Hyperdense middle cerebral artery sign. Eur J Gen Med 2006; 3:45-47
Agarwal A, Timothy J, Pandit L et al. Post traumatic Epilepsy-An over view. Clin Neurol Neurosurg. 2006; 108: 433-9.
Pandit L, Kumar S, Karunasagar I et al. Diagnosis of Partially Treated Culture Negative Bacterial Meningitis Using 16S rRNA Universal Primers and Restriction Endonuclease Digestion. J Med Microbiol.2005;54:1-4.
Karunasagar A, Pandit L, Kumar S et al I. Use of methylation sensitive PCR in the evaluation of fragile X syndrome . Ind J Med Res 2005; 122: 429-433.
Agarwal A, Pandit L, Bhandary S. et al. Extensive subdural empyema, paranasal sinusitis and orbital cellulitis complicating nasal septum surgery in a child: a case report and review of literature. Paed on call http://www.pediatriconcall.com/ fordoctor/ casereports /NasalSeptumSurgery.asp
Agarwal A, Pandit L, Dalal M et al. Neurological manifestations of Hansen's disease and their management. Clin Neurol Neurosurg 2005; 107: 445-454.
Agrawal A, Pandit L. Aetio-pathology, Diagnosis and Management of chronic neck pain. Orthopedics 2005; 7: 235-241
Thomas SV, Sarma PS, Pandit L et al. Epilepsy care in six Indian cities: a multicenter study on management and service. J Neurol Sci 2001; 188: 73-72.
Thomas SV,Sarma PS, Pandit L et al. Economic burden of epilepsy in India. Epilepsia 2001; 42:1052-60.
Pandit L, Shanker SK, Pandit A. Acute Thyrotoxic Neuropathy -Basedows Paraplegia revisited. J Neurol Sci 1998; 155: 211-214.
Pandit L, Unni N, Rao S N. Secondary Hypokalaemic Periodic Paralysis. J Assoc Physician India, 45: 421-423, 1996.
Prabhu GGL, Rao MS, Pandit L et al. Minor variant of alstrom syndrome: report of a case presenting with a perinephric abscess. Ind J Urol 1996; 12: 45-48.
Pandit L, Rao S N. Thymomatous Myasthenia Gravis. J Assoc Physician India 1995; 43: 543-545.
Pandit L, Pandit A, Aggarwal A et al.Mechanism of voiding dysfunction in the immediate Post-Stroke period. Neurol India 1994; 40: 3-5.
Pandit L, Rao S N. Computerised Tomography in Tolosa - Hunt Syndrome. Ind J Ophthalmol 1994; 42: 207-209.
Pandit L, Kapadia R, Kini P et al. Metachromatic Leukodystrophy presenting with extrapyramidal disturbances. Indian Paediatrics 1994; 31: 690-694.
Pandit L, Subramania R, Rao S N. Global aphasia without hemiparesis, clinicoradiological study of three cases. Neurol India 1992; 40: 170-181 Publications related to Drug Trials
Hauser SL, Bar-Or A, Cohen JA, et al. Ofatumumab versus Teriflunomide in Multiple Sclerosis. N Engl J Med. 2020;383(6):546-557. doi:10.1056/NEJMoa1917246
Fox RJ, Chan A, Gold R et al. Characterizing absolute lymphocyte count profiles in dimethyl fumarate-treated patients with MS: Patient management considerations. Neurol Clin Pract. 2016;6(3):220-229
Conry JA, Ng YT, Kernitsky L, et al. Stable dosages of clobazam for Lennox-Gastaut syndrome are associated with sustained drop-seizure and total-seizure improvements over 3 years. Epilepsia. 2014;55(4):558-567
Calabresi PA, Kieseier BC, Arnold DLet al; ADVANCE Study Investigators.Pegylated interferon beta-1a for relapsing-remitting multiple sclerosis (ADVANCE): a randomised, phase -3, double- blind study.Lancet Neurol. 2014; 13657-65.
Ng YT, Conry J, Pandit L et al. OV-1004 study investigators Long-term safety and efficacy of clobazam for Lennox-Gastaut syndrome: interim results of an open-label extension study.Epilepsy Behav. 2012; 25: 687-94.
Gold R, Kappos L, Pandit L et al. DEFINE Study Investigators. Placebo-controlled phase 3 study of oral BG-12 for relapsing multiple sclerosis. N Engl J Med. 2012; 367(12):1098-10.
Abraham WT, Decaux G Pandit L et al. HARMONY Study Group. Oral lixivaptan effectively increases serum sodium concentrations in outpatients with euvolemic hyponatremia. Kidney Int 2012; 82: 1215-22
Ho TW, Pearlman E, Pandit L et al. Efficacy and tolerability of rizatriptan in pediatric migraineurs: results from a randomized, double-blind, placebo-controlled trial using a novel adaptive enrichment design. Rizatriptan Protocol 082 Pediatric Migraine Study Group. Cephalalgia. 2012; 32: 750-65.
Ng YT, Conry JA, Pandit L et al. OV-1012 Study Investigators. Randomized, phase III study results of clobazam in Lennox-Gastaut syndrome. Neurology. 2011; 77:1473-81

Conference proceeding in Pubmed indexed journals

Pandit L, Cox L, Lokhande H, Rooney T, Malli C, D'Cunha A, Willocq V, Saxena S, Chitnis T. Lachnoclostridium species are elevated in aquaporin-4 (AQP4+) neuromyelitis optica patients in India and exhibit sequence similarity with AQP4. Mult Scler J 2019; 25: (S2) 131- 356.
Soares dos Reis R, Li Tsz-Ching J, Kim H, D'Cunha A, Jacob A, Berthelot E, Pandit L etal. Influence of migration on the prognosis of neuromyelitis optica spectrum disorder in non-Caucasian patients. Mult Scler J 2019; 25: (S2) 131-356
Specovius S, Zimmermann H.G, Chien C, Pandit L et al. The CROCTINO project: an international retrospective multi-center study of retinal optical coherence tomography in 501 patients with neuromyelitis optica spectrum disorders. Mult Scler J 2018;24: (s2) 530-737
Pandit L. Autoimmune Encephalitis. Mult Scler J 2018; 368-423.
hittam D, Cobo-Calvo A, Pandit L et al. Treatment of MOG-IgG- associated demyelination with Rituximab: a multinational study of 98 patients S13.003. Neurology 2018: 90 (15 Supplement)
Huda S, Orainy A, Pandit L et al. MRI abnormalities in MOG antibody disease. J Neuro Neurosurg Psychiatry 2018:89; A44-A45
Pandit L, Sato D, Siritho S et al. Characterization of seronegative neuromyelitis optica in 2016. Mult Scler J 2016; 22: (S3) 92.
Pandit L. Differentiating Multiple sclerosis from NMOSD in the clinic. Ann Ind Acad Neurol.2016. 19(S) 1-132.
Pandit L, Sato D, Mustafa Set al. Characterization Of Anti MOG and Anti AQP4 Antibody Associated NMOS in A South Indian Cohort. Mult Scler J 2015; O-2: 21.
Pandit L. Management of Multiple Sclerosis and Neuromyelitis Optica Spectrum Disorders in Resource poor settings. Mult Scler J 2015; L-16: 18.
Pandit L, Mustafa S, Malli C et al. Anti MOG antibody associated disease is distinct from Anti AQP4-IgG associated Neuromyelitis Optica Spectrum disorders. Ann Ind Acad Neurol 2015; 18: S33-34.
Sato DK, Kaneko K, Pandit L et al.Clinical phenotypes of pediatric and adult patients with anti-MOG antibodies. Mult Scler 2015; 21: (S11) 76-653.
Pandit L , Malli C, D'Cunha A et al .HLA class II alleles and environmental Associations with neuromyelitis optica in Indian population. Mult Scler 2014; 20: suppl 285- 496.
Pandit L. Genetics of multiple sclerosis in India. Mult Scler 2014; 20 (7): 902.
Pandit L,Malli C,D'Cunha A et al. Selective association of HLA -DRB1 alleles with Multiple Sclerosis susceptibility in Indian population. Mult Scler 2013; 19: (S1) 74-558.
Pandit L, Kundapur R. Mangalore model of epidemiological survey-a method for Establishing minimal prevalence for demyelinating disorders in resource poor countries. Mult Scler J 2013;19: 644- 702.
Pandit L.Genetics of Multiple sclerosis in India. Mult Scler J 2012; 18: S515-548.
Pandit L, Singhal B, Shetty R et al. Epstein -Barr serology in central nervous system demyelinating disorders from a south Indian disease registry. Mult Scler J 2011; 17: S53-S276.
Pandit L, Ban M, Sawcer N et al. Genetic risk Factors for multiple sclerosis in Indians:Do they differ from western populations? Mult Scler 2010; 16:S1268- S1273.
Pandit L,Ban M,Sawcer S,Singhal B,Nair S,Radhakrishnan K,Shetty R,Misri Z,Hegde S.Bhat I.Multiple sclerosis in India:Genetic susceptibility is not different from the west Ann Ind Acad Neurol 2010 ;13:5 SUPPL. 1 (S49)

Dr.Chaitra MalliÂ

Research Associate

Dr. AnithaÂ

Research Associate

Mrs. AkshathaÂ

Senior Research Coordinator

Current Areas of Research

This unique centre devoted to clinical and basic research in the field of Neurology came into existence in 2006. The initial funding for starting the lab was brought in by Dr. LekhaPandit and a memorandum of understanding was signed with Nitte Education Trust on 15.07.2005. Subsequent funding came from the generous support of the Nitte Trust and Governmental funding agencies such as DRDO, DST ICMR& DBT and international agencies such as Multiple Sclerosis Society of Great Britain.

Clinical Research:
Mangalore Demyelinating Disease Registry: The growing number of patients with demyelinating central nervous system disorders seen at the Department of Neurology at K S Hegde Hospital led to the formation of a patient registry exclusively for the enrollment, assessment, subsidized treatment and dedicated long term followup of patients with Multiple sclerosis, Neuromyelitisoptica and other atypical demyelinating central nervous system (CNS) disorders. The Mangalore demyelination disease Registry, run by Dr Lekha Pandit was started in 2007 with a purpose to establish a database of CNS demyelinating disorders. Patients within a radius of 250 km from Mangalore are referred for specialist consultation and treatment. This registry has more than 1500 patients on its rolls. Nearly 2/3rd are followed long-term with dedicated treatment protocols and subsidized medications. Data from this registry has led to many original contributions that help to understand autoimmune neurological disorders in the Indian context.

Laboratory Research:

Development of in-house cell based assay for the detection of AQP4 and MOGIgG antibody using Indirect Immunofluorescence technique for the sensitive diagnosis of Neuromyelitis Optica Spectrum Disorders (NMOSD).
Evaluation of the genetic susceptibility and environmental factors associated with Multiple sclerosis and Neuromyelitisoptica spectrum disorders.
Biomarker development for the detection of unknown antibodies associated with seronegative NMOSD.
Role of gut microbiome in central nervous system autoimmune disorders

Facilities

Equipments	Make
Cell culture Equipments: Fluorescent Microscope Class 2 Biological safety cabinet CO2 Incubator Flow cytometer Cell counter-Countess II FL Immunowash Microplate Washer and iMark Microplate Absorbance Reader Direct8-Milli Q- Water purification unit Ice machine	Nikon Thermo Fisher scientific (USA) Thermo Fisher scientific (USA) BD-Facsverse Thermo Fisher scientific (USA) Bio-Rad (USA) Merck Millipore Labman(India)
PCR and Electrophoresis equipments: Real time PCR Thermal cycler-PTC220 Dyad Thermal cycler- S1000 Nanodrop-2000 Spectrophotometer Gel Documentation unit HYDRASYS 2 Iso Focusing unit - Automated Agarose gel Electrophoresis System PROTEAN® i12TM IEF System and SDS PAGE unit Electrophoresis System (Horizontal) Electrophoresis System (Vertical)	7500 Applied Biosystems (USA) Bio-Rad (USA) Bio-Rad (USA) Thermo Fisher scientific (USA) VilberLourmat (France) Sebia (France) Bio-Rad (USA) Bangalore Genei Bangalore Genei
Centrifuges: Sorvall ST 8R Centrifuge Revolutionary Laboratory Centrifuge R-8C Plate Centrifuge PR-23 Refrigerated centrifuge CPR 24 Non Refrigerated High SpeedCentrifuge Refrigerated Centrifuge 5702R	Thermo Fisher scientific (USA) Remi (India) Remi (India) Remi (India) Eppendorf (Germany) Eppendorf (Germany)
Freezers and refrigerators: -80°c Deep Freezer-3 Nos -20°c Deep Freezer-Horizontal -1 No -20°c Scientific Deep Freezer Vertical -2Nos Refrigerator (150ltr) Refrigerator (350ltr) LN2 container - 2 Nos (50ltr)	New Brunswick Scientific-U570 (USA)& Thermofisher Scientific Blue Star (India) Vest frost (Germany) & Panasonic (Japan) Whirlpool LG Thermo Fisher scientific (USA)
Pipettes: Serological pipette Calibrated Micro Pipettes-6 sets (10µl, 20µl, 100µl & 1000µl) Calibrated Multi Channel Pipette(10µl) E4 XLS Electronic Multichannel Pipette	Eppendorf Eppendorf Nichipet-7000 (Japan) Rainin
Others: Digital PH meter Bar coding system-DATAMAX E 4204 Hybridization Oven Laminar Flow Units (2 Nos) Incubator Dry Bath Water Bath-2Nos Precision Weighing Scale Cyclo Mixer (3 Nos) Autoclave Unit (Vertical)- 2 Nos Microwave –oven	HANNA Bartech systems and automations Thermo Fisher scientific Lab Line( India) Kemi ( India) Remi ( India) Kemi ( India) Citizen Remi ( India) Lab Line and REMI( India) IFB

Services

Special immunodiagnostic tests are offered at Centre for Advanced Neurological Research

NMO/MOG IgG test by Indirect immunofluorescence(IIFT)
Autoimmune Encephalitis Mosaic1 IIFT test
CSF Oligoclonal Band test
Paraneoplastic Neurologic Syndrome test
ANA Global test
Granulocyte Mosaic13-ANCA test
Paraprotein Detection
Anti-thyroid antibody detection
CD19 and CD27 count by flow cytometry
Stem cell enumeration-viable CD34 count by flow cytometry

Achievements

Dr Lekha Pandit

Fulbright Nehru scholar (Academic & Professional Excellence)- 2018-2019 Visiting Professor of Neurology, Harvard Medical School, Boston, USA - 2018- 2019)
Member (Invited), International clinical consortium ,Guthy Jackson Neuromyelitis Optica foundation, USA- 2011- current
Member (nominated), Central organizing committee . Pan Asian committee for Treatment a& research in MS (PACTRIMS)- 2013- current.
Member (nominated), Medical Board, Multiple sclerosis International federation (MSIF),UK. Federation( MSIF)- 2011-2019.

Research Grants Title	Funding Agency	Amount
Use of universal primers in the diagnosis Of culture negative meningitis Use of semi nested PCR in diagnosis of Culture negative meningitis	Rhodes Scholar Mridula Shastri memorial post-doctoral scholarship (2001-2002)	Rs1, 00,000
Evaluation of Fragile X syndrome as cause of mental retardation	Indian council of medical of research (ICMR) & Nitte Educational Trust (2002-2003)	Rs25, 000
Molecular Characterization of Campylo- bacter jejuni infection associated with Guillane -Barre syndrome	Life Science research Board (DRDO,Govt of India ) (2005-2007)	Rs10, 80,000
Molecular genetics & genetic epi demiology of some common triplet repeat disorders in Coastal Karnataka	Dept.of Science & Technology, (DST,Govt of India) (2006-2009)	Rs19,00,000
A longitudinal study to determine the clinical and radiological predictors for ADEM and MS and to evaluate underlying genetic susceptibility.	Indian council of Medical research (2007-2010)	Rs 12,50,000
Evaluation of Anti Aquaporin Antibody in Indan Demyelinating disorders (collaboration with Professor Weinshenker,Mayoclinic,Minnesotta,USA)	Intramural funding (2007-2008)	Rs 1,00,000
Study of patterns and prevalence of demyelinating disorders in urban Mangalore	Indian council of medical research (2010-2013)	Rs 35,80,000
Association of HLA Class I (A&C) Alleles in Multiple Sclerosis among Indian population- a pilot study	Nitte University (2013-2014)	Rs 2,05,375
Association of H pylori with NMO and NMO spectrum disorders among Indian population	Nitte University(2014-2015)	Rs1,33,900
Study of European risk variants in MS in Indian population	MS society of Great Britain (2013-2014)	Rs 15,00,000
Environmental & genetic risk factors for MS in Indian population	Dept of Science & Technology, Govt of India (2011-2014)	Rs 58,01,282
Understanding the role of herpes viruses and human endogenous retrovirus in MS pathogenesis	Dept of Biotechnology (2014-2017)	Rs 65,00,000
Neuromyelitis optica Biomarker assay development - Phase1 (Culture & Maintenance of Human Embryonic Kidney cell lines for development of cell based biomarker assay for sensitive diagnosis of Neuromyelitis optica spectrum disorders.)	Nitte University (2015-2016)	Rs1,20,000
"Development of a cost effective cell based assay for the diagnosis of Neuromyelitis optica spectrum disorders in India"	DBT-BIRAC(2019-2021)	Rs 40,93,000
Evaluation of AQP4-IgG administration with human complement for developing Neuromyelitis optica spectrum disorder (NMOSD) rodent mouse model - A pilot study	Nitte (Deemed to be University)2019-2020	Rs 1,25,000
Use of Wistar rat brain sections in Immunohistochemistry studies for characterization of seronegative Neuromyelitis optica spectrum disorders-A pilot study	Nitte (Deemed to be University) 2019-2020	Rs 1,40,000
Indian Multiple Sclerosis and Allied Demyelinating Disorders Registry and Research Network	ICMR(2020-2025)	Rs 32,29,000
Development of a sensitive cell based assay for the detection of a diagnostic biomarker (Myelin oligodendrocyte glycoprotein antibody) in Neuromyelitis optica spectrum disorders	ICMR (2020-2023)	Rs 30,72,528
Identifying and characterizing Aquaporin -4 specific T cells in Neuromyelitis optica spectrum disorders	Nitte (Deemed to be University) 2020-2021	Rs 1,99,948

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