The Central Research Laboratory (CRL) established in 2007 serves as a central research support system to the constituent colleges of Nitte DU. The CRL has up-to-the-minute facilities to support high quality research in interdisciplinary / multidisciplinary areas to meet contemporary challenges and has collaborations with international and national organizations. Committed to enhancing research support by identifying the thrust areas of research, formulating study designs, guiding in grant applications the Centre has successfully generated substantial support from external funding agencies - BRNS, ICMR, NIH, DIBER DRDO, INMAS DRDO, VGST, CPCRI etc. It is also aided with well maintained state-of-the-art animal house facility. The Centre encourages and assists UG & PG students (both internal & external) in taking up consultancies and research projects.
1 | Organization | Purpose |
2 | ICAR-CPCRI | Antidiabetic, antiobesity, and radioprotective efficacy of tender coconut water, coconut palm sugar and virgin coconut oil |
3 | INMAS-DRDO | Biodosimetry studies |
4 | Kuvempu University (Sahyadri Science College, Shivamoga) | Unravelling the NEDD9-Vimentin nexus in Head and Neck Squamous Cell Carcinoma interceded cellular invasion and metastasis for cancer therapeutics |
5 | InARI, Bengaluru | Create training, education and research programs appropriate for Indian healthcare needs |
SL.No. | PROJECT TITLE | INVESTIGATORS | FUNDING AGENCY | DURATION |
1 + | In Vivo Studies on comparative and Synergetic Radioprotective effect of 4-Amino 5-Mercapto-3 Substituted -1,2,4-Triazole derivatives and N. jatamansi extract. | PI: Dr.SuchethaKumari N | BRNS | 2009-2012 |
2 | Value addition of different dental gels and irrigants commonly used among dental patients by exposing to electron beam irradiation | PI:Dr. A. Veena Shetty CI: K.R. Shridhar | BRNS | 2010-2013 |
3 | In vivo study of DNA damage on buccal mucosal cells by the treatment with various types of fixed orthodontic appliances. |
PI: Dr.SuchethaKumari N
CI: Dr. U.S. Krishna Nayak CI: Dilip Daniel Quadras |
ICMR | 2011-2014 |
4 | Modulatory effect of radiation on endodontic and restorative materials |
Co-PI: Dr.SuchethaKumari N PI:Dr. Mithra N Hegde |
BRNS | 2011-2014 |
5 | Evaluation and Optimization of radioprotective activity of bioactive natural and synthetic compounds on whole body electron beam irradiation |
PI: Dr. Satheesh Kumar Bhandary
PI: Dr.SuchethaKumari N PI: Dr.Vadhish Bhat |
BRNS | 2011-2014 |
6 | Biotransformation of materials used for orthodontic appliances by exposing to electron beam irradiation : An invitro study |
PI: Dr. M.S. Ravi I: Dr.SuchethaKumari N |
BRNS | 2011-2014 |
7 | Modification of radiation induced cytogenetic damages by synergistic effects of 2-deoxyglucose and Allium sativa extract on normal and tumor cells |
PI: Dr. Sukanya Shetty
PI: Dr.SuchethaKumari N |
RNS | 2011-2014 |
8 | Effect of FADS gene variants on fatty acid synthesis and brain development in India. |
Dr.SuchethaKumari N Professor Dept.of Biochemistry KSHEMA. |
NIH | 2012-2014 |
9 | Comparative and synergistic Radioprotective Effects of Cocosnucifera water and Trans- Zeatin on Electron Beam Irradiated Swiss Albino Mice |
PI: Dr.ShailajaMoodithaya Co PI: Dr.SuchethaKumari N |
BRNS | 2012-2015 |
10 | Comparative and synergistic Modulatory effects of Cassia fistula and Rhodiolarosea Leaf extracts to Protect against Electron Beam Radiation induced oxidative Damage in Human Dermal Fibroblasts (HDF). |
PI: Dr.ShettyK.Padma Co PI: Dr.SuchethaKumari N |
BRNS | 2012-2015 |
11 | A novel approach to evaluate effects of Diallyl disulfide and Carica papaya (Linn.) on hematopoietc progenitor cell Knetics in irradiated mice | PI: Dr.SuchethaKumari N | BRNS | 2012-2015 |
12 | A Novel approach to evaluate effects of diallyl disulfide and Caricca papaya (Linn.) on Hematopoietic progenitor Cell Kinetics in Irradiated Mice. | PI Dr.SuchethaKumari N Professor | BRNS | 2012-2015 |
13 | Radioprotective Effect of Tanaeetumparthenium Plant Extract with Synthetic Parthenolide on the Organs of Swiss Albino Mice | PI: Dr.Prasanth Shetty Co PI: Dr.SuchethaKumari N | BRNS | 2013-2016 |
14 | Development and validation of radioimmunoassay for the in-vitro quantitative estimation of melatonin in human serum and plasma sample | PI: Mr. ShrikantPatil | BRNS | 2013-2017 |
15 | To Investigate the ameliorative effect of lutein against electron beam-radiation-induced oxidative stress in vitro and in vivo | PI: Dr.A.P.Krishna | BRNS | 2013-2017 |
16 | Effect of Maternal Bidi Rolling on Fetal Growth and pregnancy outcome by serial Fetal Biometric and Serum Cotinine Assays: a Cohort study |
PI: Dr.RathikaD.Shenoy CI-Dr.Suchetha Kumari N |
ICMR | 2014-2017 |
17 | Evaluation of protective activity of Asparagus racemosus root extract and Isoprinosine against electron beam radiation induced immunosuppression | PI: Dr.Satheesh KumarBhandary B. | BRNS | 2014-2017 |
18 | Effect of radiation on the biomechanical behaviour of root filled teeth and radioprotective effect of remineralizing agent on the enamel |
PI-Prof.(Dr.)MithraN.Hegde CI-Dr.SuchethaKumari N. |
BRNS | 2014-2017 |
19 | Assessment of Relationship between Glycosylphosphatidylinositol and IgG Levels in Repeated Malarial Infection. | PI-Dr.SuchethaKumari N | NIH | 2014-2018 |
20 | Association of White Discharge and Psycho Social Risk Factors in Women of Reproductive Age in South Canara – A Community Based Study | PI- Dr. Lakshmi Manjeera | ICMR | 2015-18 |
21 | Electrophysiological and biochemical Indicators in Autism Spectrum Disorders | PI-Dr.Shaialaja S. Moodithaya | ICMR | 2016-18 |
22 | Bone and Joint Infections in Childrendue to CAMRSA and MSSA, A retrospective Study from Tejasvini and KSHEMA Hospitals Mangalore, India. | PI-Dr. Veena Shetty Professor Dept.of Microbiology KSHEMA | Wake Forest University | |
23 | Anti-obesity, lipid lowering and anti-inflammatory effects of virgin coconut oil on high fat diet induced obese rats”, “Anti diabetic and hypolipidemic activity of coconut palm sugar on Streptozotocin induced diabetic” and “A study on radioprotective efficacy of virgin coconut oil in swiss albino mice. | PI- Dr.SuchethaKumari N Professor Dept.of Biochemistry KSHEMA. | CPCRI | 2017-2020 |
24 | Radioprotective effect of Tanacetum parthenium (Feverfew) Plant ectract with the synthetic parthenolide on the organs of swiss albino mice. | PI- Dr. D. Prashanth Shetty | BRNS | 2013-2017 |
25 | Fund for improvement of S & T infrastructure in university and higher education institutions |
PI: Dr. Sukanya Shetty Professor Dept.of Biochemistry KSHEMA | DST-FIST | 2016-2019 |
26 | Association of insulin resistance with liver biomarkers in type 2 diabetes mellitus. | PI: Dr.Usha SachidanandaAdiga Professor Dept.of Biochemistry KSHEMA | RSSDI | 2017-2019 |
27 | "Establishment of Bio dosimetry laboratory at K.S. Hegde Medical Academy, Nitte(Deemed to be University) Mangalore and Networking with INMAS” |
Dr.SuchethaKumari N
Professor Dept.of Biochemistry KSHEMA |
INMAS, DRDO | 2017-2020 |
28 | Development Of Ganoderma Lucidum Based Health Support Products |
Dr. Suchetha Kumari N Professor Dept.of Biochemistry KSHEMA |
DIBER- DRDO | 2019-2021 |
SL.No. | PROJECT TITLE | YEAR | PRINCIPAL INVESTIGATOR | FUNDING AGENCY |
INTERNATIONAL FUNDED PROJECTS | ||||
1 | Studies on Pregnancy, delivery and child development pattern in water contaminated area of India | 2020-2025 | Dr. Dr. Suchetha Kumari N Professor Dept.of Biochemistry KSHEMA Co-PI- Dr. Shipra Sonkusare Dr. Prashant Naik Dr. Shilpa S Shetty | MEXT -GOVERNMENT OF JAPAN |
NATIONAL FUNDED PROJECTS | ||||
1 | Validation of RDT KIT for screening of Anaemia among women of child bearing age group at field level in comparing with the gold standard test in rural area of coastal Karnataka | 2021 (3 years) | Dr. Jayaprakash Shetty Professor Department of Pathology Co-PI: Dr. Nanjesh Kumar Dr. Chandrika Rao | ICMR |
2 | Establishment of Justice K S Hegde Charitable Hospital Diagnostic Centre For inherited Disorders | 2021 (3 years) | Dr. Praveen Kumar Shetty Director ((R&D)Nitte (Deemed to be University) Professor, Department of Biochemistry Co-PI Dr. Rathika Shenoy Dr. Shipra Sonkusare Dr. Prakash Patil Dr. Suchetha Kumari N | DBT-UMMID |
3 | Association of CXCL10 Gene Polymorphism and its expression with insulin resistance and severity of SARS-CoV2 infection: A Cross-sectional study | 2021 (1year) | PI: Dr. Usha Adiga Professor Dept.of Biochemistry KSHEMA Co-PI: Dr. Sudhindra Rao Dr. Sachidananda Adiga | RSSDI |
4 | “A novel dietary approach for foetal programming of major chronic disorders in adult life using Albino Wistar Rats- A case control study”. | 2019-2022 | Dr. Damodara Gowda K M Assistant Professor Dept.of Physiology KSHEMA. | ICMR |
5 | “Influence of ugtla polymorphism on sodium valproate monotherapy in paediatric epileptic patients”. | 2019-2022 | Dr.Usha Sachidananda Adiga Professor Dept.of Biochemistry KSHEMA | ICMR |
6 | Association of insulin resistance with liver biomarkers in type 2 diabetes mellitus. | 2017-2019 | Dr.Usha Sachidananda Adiga Professor Dept.of Biochemistry KSHEMA. | RSSDI |
7 | Association of single nucleotide polymorphism of Leptin gene with metabolic parameters in gestational diabetes mellitus. | 2017-2019 | Dr.Usha Sachidananda Adiga Professor Dept.of Biochemistry KSHEMA. | RSSDI |
8 | Study on Melanocytes and Epidermal Stem cells Stimulation Potential of Anti-Leucoderma Herbal Product. | 2019-2021 | Dr. Praveen Kumar Shetty Director ((R&D)Nitte (Deemed to be University) Professor, Department of Biochemistry | DIBER, DRDO |
9 | Molecular Screening of Polycystic Ovarian Syndrome (PCOS) in Dakshina Kannada | 2019-2021 | Dr. Dr. Suchetha Kumari N Professor Dept.of Biochemistry KSHEMA | VGST-KFIST |
Parameters are standardized for analysis of Serum, Saliva, Urine and other biological fluids: | ||
Total Antioxidant capacity | L-Fucose | Nitric Oxide |
Superoxide Dismutase | Sialic Acid | Catalase |
Glutathione Peroxidase | Glutathione | β-Glucuronidase |
Glutathione Transferase | Myeloperoxidase | Vitamin E |
Adenosine Deaminase | Ceruloplasmin | Mucin |
Hydrogen peroxide scavenging activity | Phosphodiesterase | Malondialdehyde |
Superoxide scavenging activity | Vitamin C | Iron |
Nitric oxide scavenging activity | Calcium | HDl Cholesterol |
C-Reactive Protein | Lactate Dehydrogenase | Glucose |
Bilirubin | Magnesium | Phosphorus |
Total Cholesterol | Total Protein | AST(SGOT) |
Alkaline Phosphatase | Albumin | ALT(SGPT) |
Triglycerides | Uric Acid | Urea |
Amylase | Creatinine | Bicarbonate |
Sodium | Potassium | Chloride |
Phytochemical Screening | Soxhlet extraction | Buffering Capacity |
pH | Electrophoresis |
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Standardized using Atomic Absorption Spectrophotometer method in Collaboration with Department of Biotechnology, Nitte Engineering College, Nitte | ||
Zinc | Lead | Nickel |
Chromium |
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Hematology Parameters | ||
Using Cell Counter, all the blood hematological parameters | ||
Radioprotective studies – In Collaboration with MicrotonCenter, Mangalore University and Oncology department, KSHEMA. | ||
Diphenylpicrylhydrazyl (DPPH) Assay | Comet Assay | Micronucleus Assay |
Ferric Reducing Antioxidant Power (FRAP) | Genotoxicity studies | Apoptosis |
Hydroxyl radical scavenging activity | Cytotoxicity Studies | Immunomodulatory studies |
ELISA TEST | ||
Ferritin | Cortisol | Interleukins |
Melatonin | SLPI | RANKL |
Osteoprotegerin | Matrix Metallo proteins | Cyclooxygenase |
Tumor necrosis factor | Heat shock proteins | Estrogen |
Lactoferrin | Insulin | Cotinine |
Vitamin D | ICTP |
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Organizations utilizing CRL facilities