Department of NUCSReM
Stem cells and cell-based therapies have tremendous potential in curing the millions of adults and children suffering from incurable diseases and medical conditions, such as Parkinson’s disease, Alzheimer’s disease, heart diseases, stroke and diabetes, osteoarthritis, birth defects, spinal cord injuries, and may also play a major role in cancer research. With the objective of harnessing the immense potential of stem cells in regenerative medicine, Nitte (Deemed to be University) started the Centre for Stem Cell Research & Regenerative Medicine (NUCSReM), in December 2013.
With state-of-the-art lab infrastructure and facilities, the NUCSReM envisages not only to further advance the understanding of basic stem cell biology but also to facilitate the clinical application of stem cells to treat patients with various disorders or injuries. To meet the global standards of stem cell research facilities for clinical applications, the NUCSReM has been set up by using the experience and expertise of biomedical engineers belonging to ChangJo Biomedical Engineering Company, Republic of Korea. The centre is presently headed by Prof. (Dr.) M. Shantharam Shetty, renowned Orthopaedic Surgeon of the country with four faculty members comprising of stem cell researchers and orthopaedic surgeons, and two adjunct faculty, Prof. (Dr.) A. Ananthram Shetty, Chair of Orthopaedics and Director of Research from Canterbury Christ Church University, Kent, United Kingdom and Prof. (Dr.) Seok Jung Kim, Director of Cell Therapy Centre, Orthopaedic Surgeon from The Catholic University of Korea, Seoul, Republic of Korea.
Among stem cells, particularly, somatic/adult stem cells (SSCs/ASCs) can be isolated not only from bone marrow, but also from other tissue sources, such as adipose tissue, muscle, umbilical cord blood, placenta, skin and dental tissues. However, the ASCs from tissues are not available in a sufficient quantity to regenerate the damaged tissues, and the in-vitro culture is needed for their isolation or expansion to obtain adequate number of cells for therapeutic use. Thus, the primary focus of the centre revolves around isolation, in-vitro characterization and differentiation forpotential autologous transplantation of patient specific stem cells, particularly for orthopaedic and dermatological applications. Further expansion of research aims to develop and utilise the patient specific induced pluripotent stem cells (iPSCs) based regenerative medicine technologies for the better treatment of various disorders and diseases. Moreover, studies on vitiligo, the skin disorder are also being carried out. The centre offers doctoral programme (PhD) in the area of ‘Stem cells and regenerative medicine’ under the faculty of Medicine and Allied Health Sciences. The research activities in the centre adheres to the National Guidelines for Stem Cell Research-2017 jointly formulated by ICMR and DBT, Govt. of India and it strictly follows the national and international standards of good manufacturing practice [GMP & current GMP (cGMP)] for processing of cells under the highest assurance of sterility, quality and documentation.
For any information regarding the admissions,mail us at: info@nitte.edu.in
Faculty
Dr. SUDHINDRA RAO M
- Designation Professor & Head
- Email sudhi78_dr@nitte.edu.in
- Joining date -
- Graduation:B.E in E&C from NIE, Mysore, India, 1986 -(FCD)
- Post-Graduation:M.Tech in CSE from MIT, Manipal, India, 1990-(FCD)
- Ph.D in CSE from University of Mysore, India, 2002
- Area of Research:CAD for VLSI - Topic: Design of Algorithms for optimum area utilization in VLSI ASICS
- Lecturer In Manipal Institute Of Technology for 6 Years
- Reader In Manipal Institute Of Technology for 3 Years
- Professor In NMAMIT for 7 Years
- Professor & Head Of Department of CSE and Dean(Academics) for 9 Years
- Professor From 2012-Till Date In NMAMIT
- Algorithm design for VLSI CAD, Multi core architecture and Program
- Optimization, Ad-hoc Networks, E-learning, Advanced Microprocessors
- Management responsibilities as Head of the Department of CSE
- Examiner for V.T.University Belagavi, Mangalore, Bangalore, Kuvempu, Kannur and Goa Universities
- Life Member of ISTE (LM816 )
- Senior Member of IEEE (01492834)
- Senior Member of CSI (F8000642)
- Fellow of IE(India)
- Logic Design
- Design and Analysis of Algorithms
- Finite Automata & formal Languages
- Computer Organization & Architecture
- Systems Programming
- RDBMS
- Microprocessors & Peripherals
- Principles of Programming Languages
- Compiler Design,
- Computer Graphics
- VLSI Design
- C# Programming & .NET Concepts
- Embedded and Real Time Systems
- Cryptography and Network Security
- MIS
- CAD for VLSI
- System simulation and Modelling.
Conference/Journal publications
- Developed "Computer Graphics Laboratory" at Manipal Institute Technology, Manipal, India in March 1988
- Reviewer for the Proceedings of IEEE Conference on "VLSI Design" since 2002.
- Chair of Programme Committee, National Conference on "Distributed Computing" , NMAMIT, Nitte India, 2004
- Coordinator for FIVE ISTE sponsored Short Term Training Programs
- Set up "Data Mining Laboratory" at NMAM Institute of Technology, Nitte during January 2006
- Chair of Organizing Committee , National Conference on "Ubiquitous & Pervasive Computing" , NMAMIT, Nitte, India, 24-25 January 2007
- So far, guided 42 BE level projects and 17 M.Tech. level projects
- President of Rotary Club of Nitte during 2006-07
- Consultant for a Patent Search organization :EntellectLLP.com
- Applied for an Indian Patent, based on research work (application no.: 428/CHE/2008)
- Applied for US Provisional Patent in April 2010 for the research work on "New Architecture for Network on chip (NoC) systems" (Application Number:61/395,480 dated 14/5/2010)
- Received AICTE travel grant for attending the conference at Shanghai, China
- Was Chairman of BOE (Board of Examination)-Computer Science at Mangalore University during 1997-98. Was member of BOE-Computer Science of Visvesvaraya Technological University ,Belgaum during 2004-05.
- BOS and BOE Chairman of NMAMIT Nitte for Computer Science UG and PG programs under Autonomous Scheme.
- Board of Studies member of Computer Science at MIT, ManipalUniversity, NMIT Bangalore, SDMCE Dharwad, BVBCE Hubli, Bangalore, Dr.AIT Bangalore and St.Aloysius College Mangalore during 2007-08
- Governing Council Member of St.John Engg. College Bangalore, Academic Council Member of Dr.AIT Bangalore from 2013.
- President of Hockey India Udupi from July 2014
- Program Chair of 2016 IEEE Distributed Computing, VLSI, Electrical Circuits and Robotics (DISCOVER) Conference, 13-14 August 2016, NITK, Surathkal
Research Collaborations
- Canterbury Christ Church University, Kent, United Kingdom
- The Catholic University of Korea, Seoul, Republic of Korea
- Mahe Institute of Dental Sciences and Hospital (MINDS), Mahe, U. T. of Puducherry
Internal funded research projects (ongoing)
| Project title with duration | Investigators (PI and Co-Is) | Budget |
|---|---|---|
| Biological and molecular characterisation of human bone marrow-derived mesenchymal stem cells as a source for cartilage regeneration (2016-19) | Dr. B. Mohana Kumar | Rs. 2.0 Lakhs |
| Evaluation of cellular properties and differentiation potential of human bone marrow-derived mesenchymal stem cells- Correlation of age to cell-based therapy outcome for delayed unions (2016-18) | Dr. Siddharth M. Shetty Dr. B. Mohana Kumar Dr. A. Veena Shetty |
Rs. 1.40 Lakhs |
| In vitro characterization of oral squamous cell carcinoma derived cancer stem-like cells(2016-18) | Dr. Varsha V. Salian Dr. B. Mohana Kumar |
Rs. 2.60 Lakhs |
| Establishment and expression of markers in stem/progenitor cells from human tympanic membrane (2017-18) | Prof. (Dr.) B. Satheesh Kumar Bhandary Dr. B. Mohana Kumar Dr. Shama Rao |
Rs. 1.10 Lakhs |
| Establishment and characterization of melanocytes from vitiligo patients (2017-19) | Dr. Shricharith Shetty Dr. B. Mohana Kumar Dr. Basan Gowda S. Kurkalli |
Rs. 2.50 Lakhs |
| Characterization and multilineage differentiation of stem cells derived from human dermal skin (2017-19) | Dr. Nikhil S. Shetty Dr. B. Mohana Kumar Dr. A. Veena Shetty |
Rs. 2.00 Lakhs |
| Comparison of interaction of dental pulp and dental follicular stem cells in bone regeneration on titanium implants- an in vitro study (2017-18) | Prof. (Dr.) Chethan Hegde Dr. Basan Gowda S. Kurkalli Dr. Sushmita V. P. |
Rs. 1.00 Lakhs |
Ongoing NitteDU research projects
Achievements
- “Outstanding Clinical Excellence” award from UK’s House of Lords to Prof. (Dr.) A. Ananthram Shetty, Adjunct Professor Prof. (Dr.) A. Ananthram Shetty, renowned Orthopaedic Surgeon at Canterbury Christ Church University, Kent, United Kingdom (UK) and an Adjunct Professor at Nitte University Centre for Stem Cell Research and Regenerative Medicine (NUCSReM) has been honoured with “Outstanding Clinical Excellence” award by the UK’s House of Lords.
Prof. Dr. M. SHANTHARAM SHETTY
- Designation Pro-Chancellor, Nitte
- Contact No.
- Joining date
MS (Ortho.), FICS (Ortho), FIAMS
Prof. Dr. A. ANANTHRAM SHETTY
- Designation
- Contact No.
- Joining date
PhD, MCh Orth., FRCS Ed., FRCS Eng., FRCP & S (Glas.), FRCS Orth
Prof. Dr. SEOK JUNG KIM
- Designation
- Contact No.
- Joining date
MD, PhD, FRCS Eng.
Dr. A. VEENA SHETTY
- Designation Addl. Professor &Research Co-ordinator
- Contact No.
- Joining date
MSc, PhD
Dr. B. MOHANA KUMAR
- Designation Associate Professor
- Email mohanakumar@nitte.edu.in
- Contact No.
- Joining date
MFSc, PhD, Post-Doc (Republic of Korea, Canada)
- Advanced research on the cellular, molecular and functional mechanisms of human tissue-specific stem cells and induced pluripotent stem cells (iPSCs) and their potential applications in regenerative therapies, disease modeling and drug development
- Early and late translational research on stem cell- and cell-free based therapies in the areas of Orthopaedics, Dermatology, ENT and Dentistry
- Serving as a Guide for PhD, and Co-guide for dental and medical post-graduate students.
- Post-doctoral fellowship (2004-2006) from Korea Science and Engineering Foundation (KOSEF), Republic of Korea
- Senior researcher fellowship (2010-2013) from National Research Foundation (NRF), Ministry of Education, Science and Technology, Republic of Korea.
- Shantharam Shetty M, Ajith Kumar M, Mohana Kumar B. 2018. Bone marrow aspirate concentrate in non-union bones: Methodology and our experience. Journal of Postgraduate Education and Research, April-June Issue, 52 (2): 94-96
- Narendra N, Shama Rao, Siddharth Shetty M, Veena Shetty A, Shantharam Shetty M, Mohana Kumar B. 2020. Cellular properties and multilineage potential of bone marrow mesenchymal stem cells for cartilage regeneration. Research Journal of Biotechnology 15(8):58-65
- Kaniyattu SM, Meenakshi A, Karuna R, Mohana Kumar B, Shama Rao, Prashanth Shetty D, Vijith Shetty, Jayaprakash Shetty K, Padma Shetty K. 2020. Cytogenetic and cytokine profile in elderly patients with cytopenia. Experimental Hematology 89: 80-86
- Shama Rao, Siddharth Shetty M, Narendra N, Veena Shetty A, Guruprasad KP, Mohana Kumar B. 2020. Characterization of synovium-derived mesenchymal stem cells from joints with osteochondritis dissecans. Biomedical Research and Therapy 7(10): 4075-4085
- Akshay BM, Shama Rao, Siddharth Shetty M, Veena Shetty A, Ananthram Shetty A, Shantharam Shetty M, Mohana Kumar B. 2021. Characterisation of human cartilage-derived mesenchymal progenitor cells from osteoarthritis patients. Journal of Advanced Biotechnology and Experimental Therapeutics 4(2): 200-209.
- Cell and molecular biology
- Stem cells and developmental biology
- Cell and stem cell-based therapies
Ongoing Projects
- Optimizing the generation of human umbilical cord blood-derived mesenchymal stem cells for potential clinical use- NitteDU (Intramural)
- Characterization of human hair follicle stem cells for potential clinical applications- NitteDU (Intramural)
- Characterization of epidermal stem cells from human tympanic membrane for potential tissue engineering applications- NitteDU (Intramural)
- Evaluation of potency characteristics of bone marrow mesenchymal stem cells and clinical outcomes of avascular necrosis of femoral head- NitteDU (Intramural)
- Purification and therapeutic potential of lubricin derived from synovial mesenchymal stem cells for osteoarthritis- NitteDU (Intramural)
- In vitro evaluation of buccal fat pad as a prospective source of multipotent stem cells for applications in oral and maxillofacial surgery- NitteDU (Intramural)
- Biological and molecular characterization of human bone marrow-derived mesenchymal stem cells as a source for cartilage regeneration- NitteDU (Intramural)
- Isolation, characterization and differentiation of human synovial tissue derived mesenchymal stem cells- NitteDU (Intramural)
- Establishment and characterization of melanocytes from vitiligo patients- NitteDU (Intramural)
- Establishment and expression of markers in stem/progenitor cells from human tympanic membrane- NitteDU (Intramural)
- Characterization and multilineage differentiation of stem cells derived from human dermal skin- NitteDU (Intramural)
- Phenotypic and differentiation characteristics of mesenchymal stem cells derived from human gingiva and periodontal ligament- NitteDU (Intramural)
- Establishment and basic characterization of gingiva derived mesenchymal stem cells from periodontally healthy and diseased subjects- NitteDU (Intramural)
- Adhesion, proliferation, migration and integrin expression of human periodontal ligament stem cells cultured on different guided tissue regeneration membranes- NitteDU (Intramural)
- Biological characterization of fresh and cryopreserved dental pulp stem cells derived from third molar teeth: a comparative study- NitteDU (Intramural)
- Immunomodulatory plasticity of primed gingiva derived mesenchymal stem cells obtained from periodontally healthy and diseased subjects- NitteDU (Intramural)
Professional positions
- Member, Research Advisory Committee, Nitte (DU)
- Internal Expert, Institutional Biosafety Committee, Nitte (DU)
- Member Secretary, Scientific Committee, Nitte (DU)
- Member, Institutional Ethics Committee, KSHEMA
- Member, Institutional Research Advisory Committee, NUCSER
- Subject Expert, Institutional Animal Ethics Committee, NGSMIPS
- Member, Institutional Research Cell Committee (IRCC), KSHEMA
- Member, International Society for Stem Cell Research (ISSCR), USA
- Member, International Society for Cell and Gene Therapy (ISCT), USA
- 60 publications in International peer reviewed scientific journals
- 14 National peer reviewed scientific journals
- 2 chapters in books by International publishers
- Total citations- 1607; h-index- 23; i10-index- 31
Dr. SIDDHARTH M. SHETTY
- Designation Addl. Professor
- Contact No.
- Joining date
MBBS, DNB (Ortho.)
Dr. SHAMA RAO
- Designation Research Assistant
- Email .
- Contact No. .
- Joining date
- Radiation biology
- Cell and molecular biology
- Stem cells and regenerative medicine
Mr. JAYAPRAKASHA SHETTY
- Designation Lab Assistant
- Email .
- Contact No. .
- Joining date
- Cell biology
- Adult stem cells and their applications
